He whose purposed actions are never obstructed by heat or cold, fear or attachment, prosperity or adversity, is considered wise. He whose judgment dissociated from desire, followeth both virtue and profit, and who disregarding pleasure chooseth such ends as are serviceable in both worlds, is considered wise. They that exert to the best of their might, and act also to the best of their might, and disregard nothing as insignificant, are called wise.

In plain words: A wise person is not stopped by heat or cold, fear or attachment, good times or bad. They choose what is right and useful over mere pleasure, aiming for things that help in this life and the next. They try their best, act their best, and treat nothing as too small to matter.